A detailed, modern digest of key advances in the diagnosis, treatment, and management of patients with Duchenne muscular dystrophy.
Learning Objective
After completing this educational activity, you should be able to:
Join Leo Wang and Maya Hatch for an insightful journey into the world of Facioscapulohumeral Muscle Dystrophy (FSHD), covering its etiology, clinical presentations, and the complexities of assessing treatment outcomes in clinical trials. Key focuses include the innovative Reachable Workspace (RWS) metric for functional assessment, the impact of current clinical trials, and emerging therapeutic targets. Discussions will also highlight biomarker insights, disease mechanisms like DUX4 regulation, and future strategies for FSHD management. Don’t miss this opportunity to gain insights from experts shaping the future of FSHD research and care, along with perspective from a real-world patient living with FSHD.
Alzheimer’s Disease (AD) is a debilitating condition marked by amyloid plaques and neurofibrillary tangles in the brain, affecting over 6 million Americans—a number expected to nearly double in the next 30 years [Alzheimer’s Association 2023]. Early detection and prevention of plaque buildup are crucial in combating the disease. Recent advances in biomarker technology are reshaping diagnosis and treatment. This session will cover key biomarkers for early screening, evaluate approved and investigational therapies, and explore methods for early-stage detection, including cognitive tests and imaging. Join us to stay at the forefront of Alzheimer’s care and research.
This program brings together leading experts to explore advancements in the diagnosis and treatment of Alzheimer’s disease (AD). Presented by Marc E. Agronin, MD, R. Scott Turner, PhD, MD, and Susan Scanland, MSN, this program addresses key challenges and solutions in AD care. Topics include strategies for early detection and diagnosis through cognitive assessments, neuroimaging, and biomarker analysis; the role of novel and investigational disease-modifying therapies and the integration of therapeutic approaches, including FDA-approved treatments and nonpharmacologic interventions. The session emphasizes the importance of multidisciplinary management and shared decision-making with patients and caregivers to create comprehensive and effective care plans.
This educational activity, presented by Dr. Deligiannidis, Dr. Vega, and Dr. Smith, offers clinicians an essential update on perinatal depression (PND), including its pathophysiology, diagnosis, and treatment options. With a focus on the latest research and therapeutic advancements, this session highlights the significant impact of timely diagnosis and the risks of delayed intervention.
Participants will explore the neurobiological underpinnings of PND, including mechanisms such as altered GABAergic neurotransmission and the roles of neuroactive steroids like allopregnanolone. The presentation also reviews evidence-based approaches, covering both traditional antidepressants (SSRIs, SNRIs, TCAs) and innovative treatments like brexanolone and zuranolone. Practical insights on real-world applications, including considerations for the post-COVID era, provide clinicians with actionable knowledge to enhance care for patients affected by PND.
Join us for a dynamic one-hour CME activity on Parkinson’s Disease Psychosis (PDP) with top experts Mark F. Lew, MD, and Jennifer Hui, MD. Unlock the latest best practices for diagnosing PDP and implementing cutting-edge therapies. The session kicks off with a deep dive into Parkinson’s Disease, covering its prevalence, motor and nonmotor symptoms, and the unique challenges of PDP. Next, master the intricacies of recognizing and diagnosing PDP with the newest diagnostic criteria and screening tools. Finally, conquer PDP treatment and management strategies, including behavioral approaches, medication adjustments, and safe antipsychotic options. Plus, gain invaluable insights from the caregiver of a real-world patient with PDP, providing a firsthand perspective on managing this complex condition. Boost your clinical expertise and transform patient care with this essential update on managing Parkinson’s Disease Psychosis.
Delve into the cutting-edge advancements in Facioscapulohumeral Muscular Dystrophy (FSHD) alongside the dynamic duo of Dr. Leo H. Wang and Dr. Maya N. Hatch in this symposium recorded at the 2024 MDA Clinical & Scientific Conference Summit. Positioned as the third most prevalent muscular dystrophy, FSHD stands as a genetic enigma with intricate roots, showcasing a progressive saga of asymmetrical muscle weakness. Initially targeting the facial and shoulder muscles before spreading its grip onto the extremities, this disorder's clinical narrative presents a formidable challenge in quantifying outcomes. It's an imperative moment to unearth dependable and sensitive metrics for clinical trials, navigating the labyrinthine landscape of FSHD. Acquire invaluable insights into mastering daily functionalities, tackling complications head-on, and remain abreast of the latest breakthroughs in establishing rock-solid measures for gauging progress.
CME credit for physicians or CE participation credit for nonphysicians is awarded for reviews submitted in a timely manner and in recognition of the learning that takes place during a manuscript review.
You will be awarded 3.00 AMA PRA Category 1 CreditTM for this activity. The ACCME allows up to 15.00 AMA PRA Category 1 CreditTM for peer review to be claimed each year.
We anticipate learners will make improvements in their ability to critically review research manuscripts, as well as incorporate new research findings into their own practice as appropriate.
The CME Institute adheres to the Standards for Integrity and Independence in Accredited Continuing Education of the Accreditation Council for Continuing Medical Education (ACCME). Any individuals in a position to control the content of a continuing education activity, including faculty, content developers, reviewers, staff, and others, are required to disclose to learners the presence or absence of any relevant financial relationships with an ACCME-defined ineligible company within the preceding 24 months of the activity. The ACCME defines an “ineligible company” as one whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
The CME Institute has mitigated all relevant conflicts of interest prior to the commencement of the activity. None of the individuals involved in the content have relevant financial relationships with ineligible companies except the following:
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Larry Culpepper, MD, MPH (Editor in Chief, The Primary Care Companion for CNS Disorders), is affiliated with the Department of Family Medicine, Boston University School of Medicine, Boston, Massachusetts, and in the past year, has been an advisor for AbbVie, Eisai, and Supernus; has been a stock shareholder of M-3 Information; and has received royalties from UpToDate. |
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Marlene P. Freeman, MD (Editor in Chief, The Journal of Clinical Psychiatry [JCP]), is affiliated with Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts (MGH) and works with the MGH National Pregnancy Registry for which the current sponsors are Alkermes, Inc. (2016-Present); Aurobindo Pharma (2020-Present); AuroMedics Pharma LLC (2021-present); Johnson & Johnson/Janssen Pharmaceuticals, Inc (2019-Present); Otsuka America Pharmaceutical, Inc. (2008-Present); Sage Therapeutics (2019-Present); Sunovion Pharmaceuticals, Inc. (2011-Present); Supernus Pharmaceuticals (2021-Present); and Teva Pharmaceutical Industries Ltd. (2018-Present). Past Sponsors were Forest/Actavis/Allergan (2016-2018, declined to sponsor: 2018-Present), AstraZeneca Pharmaceuticals (2009-2014, declined to sponsor: 2014-Present); Ortho-McNeil-Janssen Pharmaceuticals, Inc (2009-2014, declined to sponsor: 2015-Present); and Pfizer Inc (2009-2011, declined to sponsor: 2012-Present). As an employee of MGH, Dr Freeman works with the MGH CTNI, which has received research funding from multiple pharmaceutical companies and NIMH. Dr Freeman has also received research support from Investigator Initiated Trials /Research: JayMac and Sage; been on the advisory boards for Eliem and Sage and Independent Data Safety and Monitoring Committees: Janssen (Johnson & Johnson), Novartis, and Neurocrine; received honoraria for speaking and planning of educational activities for WebMD, Medscape, Pri-Med, and Postpartum Support International; and received Scale Royalties (through MGH) for The Massachusetts General Hospital Female Reproductive Lifecycle and Hormones Questionnaire (Freeman et al. 2013). |
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Philippe Courtet, MD, PhD (JCP Section Editor, Focus on Suicide), is affiliated with FondaMental Fondation, Créteil, France, and has received consulting fees from Pfizer Inc, honoraria for speaking/teaching from Janssen Cilag, and advisory board fees from Ethypharm Digital Therapy and Janssen Cilag in the past 24 months. |
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Jordan F. Karp, MD (JCP Section Editor, Focus on Geriatric Psychiatry), is affiliated with the Department of Psychiatry, College of Medicine, University of Arizona, Tucson, Arizona; owns equity interest/stocks in privately held company Aifred Health and has received grant/research support from NIH and PCORI (Patient-Centered Outcomes Research Institute) and advisory board fees from Biogen, which has now ended. |
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Joseph F. Goldberg, MD (JCP Section Editor, Early Career Psychiatrists), is affiliated with the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; has received consulting fees from BioXcel, Lundbeck, Otsuka, Sage Pharmaceuticals, Sunovion, and Supernus; honoraria for speaking/teaching from Abbvie, Alkermes, Axsome, Intracellular Therapies, and Sunovion; and royalties from American Psychiatric Publishing and Cambridge University Press. He is on the advisory board for Jazz Pharmaceuticals. |
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Ann K. Shinn, MD, MPH (JCP Section Editor, Focus on Psychosis), is affiliated with the Psychotic Disorders Division, McLean Hospital/Harvard Medical School Department of Psychiatry, Belmont, Massachusetts, and has no financial relationships with any ACCME-defined ineligible company in the past 24 months. |
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Gary W. Small, MD (JCP Section Editor, Focus on Geriatric Psychiatry), is affiliated with Hackensack Meridian Health, Hackensack University Medical Center Edison, New Jersey, and has received consulting and advisory board fees from AARP, Acadia, Allergan, Avanir, Biogen, Gerontological Society of America, Handok, Herbalife, Lundbeck, Lilly, McCormick Science Institute, Otsuka, Reckitt Benckiser, Roche, and Theravalues. |
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Karen D. Wagner, MD, PhD (JCP Section Editor, Focus on Childhood and Adolescent Mental Health), is affiliated with the Department of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, Galveston, Texas, and has no financial relationships with any ACCME-defined ineligible company in the past 24 months. |
To be awarded credit and receive a certificate for this activity, peer-review learners must have completed their peer review in a timely manner and have provided constructive criticism to the author and Editor. The peer reviewer must complete the following Evaluation form to claim credit.
You will be awarded 3.00 AMA PRA Category 1 CreditTM for this activity. The ACCME allows up to 15.00 AMA PRA Category 1 CreditTM for peer review to be claimed each year.
The CME Institute of Physicians Postgraduate Press, Inc., is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The CME Institute of Physicians Postgraduate Press, Inc., designates this manuscript review activity for a maximum of 3.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Note: The American Nurses Credentialing Center (ANCC) and the American Academy of Physician Assistants (AAPA) accept certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
To obtain credit for this activity, study the material and complete the Evaluation.
No financial support has been received for this activity.